管剑龙

社会任职

兼任复旦大学风湿免疫过敏性疾病研究中心副主任、上海医学会风湿专科分会副主任委员、上海中西医结合风湿病学会副主任委员、上海中西医结合学会白塞病学组组长、上海中医药学会风湿病分会常委、上海医学会系统性血管炎学组副组长、中国中西医结合学会风湿性疾病分会委员、中国医师学会风湿免疫科分会委员、海峡两岸医药卫生协会风湿病委员会常委、海峡两岸医药卫生协会风湿病委员会委员血管炎学组常委、卫生部中国医疗保健国际交流促进会氢离子分会委员、北京白求恩奖励基金会风湿免疫分会委员、上海医学会风湿病专科分会委员、上海医师学会风湿病分会委员、上海市医学会第四届医疗鉴定专家、上海市干部保健局专家、国家卫计委风湿免疫频道、医师报编委会编委和Journal of Autoimmune diseases & Rheumatology等国内外多种杂志审稿专家和编委等。

获奖荣誉

曾获省部科技进步一等奖、优秀发明二等奖、军队医疗成果三等奖、第二军医大学教学成果一等奖、上海医科大学“光华奖”；获中央军委通令嘉奖、首都抗非典先进个人、小汤山医院感染控制先进个人、第二军医大学、华东医院优秀党员、解放军总后勤部集体二等和三等功等。

科研成果

主编《白塞病新概念》、《中国骨关节炎十年》、《风湿病学临床实践指南》专著三部，副主编著作《临床疾病诊治最新进展》、《现代风湿病药物治疗学》、《内科症状鉴别诊断学》3部，参编《实用内科学》等著作30余部；截止2021年10月8日发表学术论文198篇，SCI论文56篇。负责国家自然科学基金面上项目3项“81072478、81273298和81871276”、上海市科委重点科研课题 (05JC14034)、中华医学会专项基金(08010260104) 、上海申康医院发展中心白塞病科技创新课题、第二军医大学重点教学改革科研课题、上海卫计委2015-2017年度罕见病（白塞病）重点攻关项目（2014ZYJB0010）等共21项。
学术论文2018-2021
白塞病的重新定义，已经积累了丰富的临床经验，中国28位中西医专家已经达成共识，科研论文得到国外临床和科研专家的肯定。目前，新定义：白塞综合征又称丝绸之路病，是一种以复发性口腔溃疡为最常见首发症状、逐渐伴发外阴溃疡、结节性红斑、毛囊炎等皮肤粘膜病变为基本临床特征，可能逐步选择性发生眼炎、肠溃疡、主动脉瓣返流、静脉血栓、动脉瘤、动脉狭窄、关节炎、神经损害或血细胞减少症等1～2个寡器官损害的变异性血管炎。并率先将白塞病分为皮肤黏膜型白塞病、眼白塞病、肠白塞病、心脏白塞病、血管白塞病、神经白塞病、血液白塞病和关节白塞病共8个临床表型。
[1]Jing-fen Ye, Cheng-cheng Hou, Hua-fang Bao, Jian-long Guan*. New insight into the features of Behçet's disease with gastrointestinal ulcer: a cross-sectional observational study. Orphanet J Rare Dis, 2021, 16(1):444.
[2]Cheng-cheng Hou, Hua-fang Bao, Yan Shen, Jing-fen Ye, Hai-fen Ma, Jian-long Guan*. Expression of miRNAs derived from plasma exosomes in patients with intestinal Behçet's syndrome. Clin Exp Rheumatol, 2021, Oct 19. Epub ahead of print. PMID: 34665700.
[3]Cheng-cheng Hou, Hai-fen Ma, Jing-fen Ye, Dan Luo, Hua-fang Bao, Jian-long Guan*. Plasma exosomes derived from patients with intestinal Behçet's syndrome induce intestinal epithelial cell pyroptosis. Clin Rheumatol, 2021, 40(10):4143-4155.
[4]Cheng-cheng Hou, Jing-fen Ye, Hai-fen Ma, Jian-long Guan*. Clinical characteristics and risk factors of intestinal involvement in Behçet’s syndrome patients: a cross-sectional study from a single center. Orphanet J Rare Dis, 2021, 16(1):132.
[5]Jun Zou, Jian-feng Luo, Yan Shen, jian-long Guan*. Distinct clinical characteristics of pediatric Behçet’s syndrome: A study from a referral center in China. Mod Rheumatol, 2021, 16:1-6.
[6]Jun Zou, Jian-feng Luo, Yan Shen, Jian-fei Cai, Jian-long Guan*. Cluster analysis of phenotypes of patients with Behçet's syndrome: a large cohort study from a referral center in China. Arthritis Res Ther, 2021, 23(1):1-9.
[7]Jun Zou, Chen-Hong Lin, Yan Wang, Yan Shen, Jian-Long Guan*. Correspondence on 'A pilot study of tofacitinib for refractory Behçet's syndrome'. Ann Rheum Dis, 2021, 1(1). 1-2
[8]Jun Zou, Dan Luo, Yan Shen, Jian-long Guan*. Characteristics and phenotype heterogeneity in Late-onset Behçet’s syndrome: A cohort from a referral center in China. Clin Rheumatol, 2021, 12: 1-20.
[9]Cheng-cheng Hou, Jian-long Guan*. Risk factors of disease activity in patients with Behçet’s syndrome. Clin Rheumatol, 2020, 1(1): 1-7
[10]Yan Shen#, Haifen Ma#, Dan Luo, Jianfei Cai, Jun Zou, Zhijun Bao*, Jian-long Guan*. Behcet's disease with latent Mycobacterium tuberculosis infection. Open Medicine, 2020, 16(1):14-22.
[11]Jianfei Cai, Lin Qi, Yong Chen, Jun Zou, Yan Shen, Dan Luo, Huafang Bao, Jingfen Ye, Haifen Ma, Jian-Long Guan*. Evaluation of factors for predicting risk of uveitis recurrence in Behcet’s disease patients. Braz J Med Biol Res, 2020, 53(00): e9118.
[12]Chen-Hong Lin, Dan Luo, Hai-Fen Ma, Yan Shen, Jun Zou, Jian-Long Guan*. Clinical characteristics and factors influencing the prognosis of Behçet’s disease complicated with vascular involvement. Vasa. 2020 Mar 31, 1-8. doi: 10.1024/0301-1526/a000859.
[13]Liang Zhang, Yun Tian, Jing-Fen Ye, Chen-Hong Lin, Jian-Long Guan*. Prognostic Factors in Patients with Newly Diagnosed Intestinal Adamantiades-Behçet's Disease in the Shanghai Adamantiades-Behçet's Disease Database: A Prospective Cohort Study. Orphanet J Rare Dis. 2019,14(1):274. doi: 10.1186/s13023-019-1228-9.
[14]Yan Shen, Jian-long Guan*. Ulcerative intestinal tuberculosis case as a complication of treatment by infliximab for intestinal Behçet’s disease. Medicine, 2019.10, 2019: 1-5
[15]Chen yong, Guan Jian-long*. Demography of vascular Behcets disease with different gender and age an investigation with 166 Chinese patients. Orphanet J Rare Dis, 2019, 1(1): 2-8
[16]Chen yong, Guan Jian-long*. Efficacy and safety of metformin for Behcet's disease and its effect on Treg/Th17 balance: a single-blinded, before-after study.J South Med Univ, 2019, 39(2): 127-133
[17]Ye Jing-fen, Guan Jian-long*. Incidence and risk factors for anemia among newly-diagnosed intestinal Behcet’s disease patients. JNMA, 2019, 1(1): 1-5
[18]Chen Yong, Guan Jian-long*. Reply to “Comment to Deep vein thrombosis induced by vasculitis in the Behçet’s syndrome”. CMJ, 2019, 132(2): 505-506
[19]Shen Yan, Ma Hai-Fen , Luo Dan, Guan Jian-Long*. The T-SPOT.TB assay used for screening and monitoring of latent tuberculosis infection in patients with Behçet’s disease pre- and post-anti-TNF treatment: A retrospective study. J Chin Med Assoc, 2019, 85(2): 375-381
[20]Ye Jing-fen, Guan Jian-long*. Differentiation between Intestinal Behçet’s Disease and Crohn’s Disease Based on Endoscopy. Turk J Med Sci, 2018.12, 48: 1807-1867.
[21]Chen Yong, Luo dan, Cai Jian-Fei, Chen-Hong Lin, Yan Shen, Zou Jun, Guan Jian-long*. Effectiveness and safety of Glycyrrhizae Decoction for Purging Stomach-Fire in Behcet disease patients. Medicine, 2018, 97(13): 1-7.
[22]Yan Shen, Hai-fenma,Luo dan, Cai Jian-Fei, Zou Jun, Guan Jian-long*. High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Behçet’s Disease Associated with Myelodysplastic Syndrome: A Series of 16 Disease Database and Comparison with the Literature. Biomed Res Int, 2018, 8535091: 1-10.
[23]Chen Yong, Guan Jian-long*. Is Warfarin Indicated in Behcet’s Syndrome Associated with Thrombosis Reflections on Treatment and Death of a Patient? Chin Med J, 2018, 131(1): 105-106.
[24]Dan Luo, Yan Shen, lyu Jian-qiang, Fan Yong-Qian, Huang Dong-Hui, Lin Wei-Long, Shen Hai-Min, Xu Hu-Ji. Guan Jian-long*. Mechanical stress in combination with verapamil increases levels of aggrecan and decreases levels of ADAMTS-5 mRNAs and proteins in human osteoarthritic chondrocyte/agarose constructs. Chin Med J, 2018, 131: 376-377.
[25]Chen Yong, Gu Feng, Guan Jian-long*. Metformin Might Inhibit Virus through Increasing Insulin Sensitivity. Chin Med J, 2018, 131(3): 376-377.
[26] Cai Jian-Fei, Yinjia Zhang, Zou Jun, Yan Shen, Luo dan, Bao Hua-Fang, Chen Yong, Ye Jing-fen, Guan Jian-long*. Serum uric acid could be served as an independent marker for increased risk and severity of ascending aortic dilatation in Behçet's disease patients. J Clin Lab Anal, 2018, e22637: 1-6.

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